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  Indian J Med Microbiol
 

Figure 2: Schematic of (A) the calcium-sensing receptor gene promoters, (B) the calcium-sensing receptor gene exon/intron organization, and (C) calcium-sensing receptor protein. (A) CCAAT and TATA boxes and SP-1 are the sites that drive transcription of exon 1A and 1B respectively. Bolded: those shown to be functionally active. Not bolded: those predicted but either not functionally active or not yet evaluated. (B) Exon/intron organization of the calcium-sensing receptor gene. White bars: mRNA untranslated (exons; 1A, 1B, part of 2, part of 7). Gray bars: mRNA protein coding (exons; part of 2, 3–6, part of exon 7). ATG: Initiation codon. TAA: Stop codon. AATAAA: Polyadenylation signals. Alternative splicing of exons 1A and 1B to exon 2 is shown. *Alternative transcript lacking exon 5. Black arrowhead: alternative transcript having additional 30 bases at the beginning of exon 6. (C) Calcium-sensing receptor protein: 1078 amino acid protein encoded by exons 2–7. *Minus 77 aa encoded by exon 5. Open arrowhead: additional 10 aa encoded by extra 30 bases of alternative RNA transcript

Figure 2: Schematic of (A) the calcium-sensing receptor gene promoters, (B) the calcium-sensing receptor gene exon/intron organization, and (C) calcium-sensing receptor protein. (A) CCAAT and TATA boxes and SP-1 are the sites that drive transcription of exon 1A and 1B respectively. Bolded: those shown to be functionally active. Not bolded: those predicted but either not functionally active or not yet evaluated. (B) Exon/intron organization of the calcium-sensing receptor gene. White bars: mRNA untranslated (exons; 1A, 1B, part of 2, part of 7). Gray bars: mRNA protein coding (exons; part of 2, 3–6, part of exon 7). ATG: Initiation codon. TAA: Stop codon. AATAAA: Polyadenylation signals. Alternative splicing of exons 1A and 1B to exon 2 is shown. *Alternative transcript lacking exon 5. Black arrowhead: alternative transcript having additional 30 bases at the beginning of exon 6. (C) Calcium-sensing receptor protein: 1078 amino acid protein encoded by exons 2–7. *Minus 77 aa encoded by exon 5. Open arrowhead: additional 10 aa encoded by extra 30 bases of alternative RNA transcript