Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 254
  • Home
  • Print this page
  • Email this page
Cover page of the Journal of Health Sciences
REVIEW ARTICLE
Year : 2022  |  Volume : 15  |  Issue : 2  |  Page : 114-120

Association of human leukocyte antigen-G 14-bp insertion/deletion and +3142G>C polymorphisms with rheumatoid arthritis: A meta-analysis


1 Department of Zoology, University of Gour Banga; Department of Zoology, Malda College, Malda, West Bengal, India
2 Department of Zoology, University of Gour Banga, Malda, West Bengal, India

Correspondence Address:
Dr Manoj Lama
Molecular Immunology Laboratory, Department of Zoology, University of Gour Banga, Malda - 732 103, West Bengal
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/kleuhsj.kleuhsj_391_21

Rights and Permissions

This meta-analysis investigated the significant association between human leukocyte antigen (HLA)-G 14-bp insertion/deletion and +3142G>C polymorphisms with susceptibility to rheumatoid arthritis (RA). This relationship has been scrutinized in several studies, and the findings are controversial. The association studies related to HLA-G gene polymorphisms and RA were extracted from PubMed, Mendeley, ScienceDirect, and Google Scholar databases up to December 31, 2020. Finally, a total of 1516 cases and 1683 control samples were chosen from 7 published research articles for this meta-analysis. A significant association was evaluated using the pooled odds ratios (ORs) and 95% confidence intervals (CIs) under allelic, dominant, recessive, and additive models. Overall, there is absence of significant association between 14-bp ins/del polymorphism and RA (recessive model: OR = 1.012, 95% CI = 0.841–1.217, P = 0.900; dominant model: OR = 1.068, 95% CI = 0.919–1.241, P = 0.393; ins/ins vs. del/del: OR = 1.059, 95% CI = 0.861–1.303, P = 0.587). In the case of +3142G>C polymorphism, the recessive model (OR = 1.332, 95% CI = 1.083–1.640, P = 0.007) showed a significant association with RA susceptibility. When subgroup analysis was done by ethnicity, +3142G>C polymorphism was found to be significantly associated with RA susceptibility in the Asian population under the recessive model (OR = 1.450, 95% CI = 1.048–2.006, P = 0.025). This meta-analysis brings to light that there was no significant association between 14-bp ins/del polymorphism and RA susceptibility. Whereas, +3142G>C polymorphism was found to be significantly associated with susceptibility to RA.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed272    
    Printed10    
    Emailed0    
    PDF Downloaded54    
    Comments [Add]    

Recommend this journal