Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 446
  • Home
  • Print this page
  • Email this page
Cover page of the Journal of Health Sciences
ORIGINAL ARTICLE
Year : 2021  |  Volume : 14  |  Issue : 3  |  Page : 370-374

Importance of platelet indices in the establishment of etiopathological categorization of thrombocytopenia in children


1 Department of Pathology, Dr. B.C. Roy PGIPS, Kolkata, West Bengal, India
2 Department of Anatomy, Institute of Post-Graduate Medical Education and Research, Kolkata, West Bengal, India
3 Department of Microbiology, Bankura Sammilani Medical College, Bankura, West Bengal, India

Correspondence Address:
Dr. Arijit Majumdar
C/o Sanat Kumar Majumdar, Opposite Duilya Panchayat Office, Charaktala, Mourigram, Andul, Howrah - 711 302, West Bengal
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/kleuhsj.kleuhsj_331_20

Rights and Permissions

BACKGROUND: Evaluation of thrombocytopenia requires thorough clinical history, examination, complete hemogram, including platelet indices and bone marrow study whenever indicated. The etiopathogenetic mechanism decides patient management. Platelet-derived indices have a well-established correlation with the differential diagnosis of thrombocytopenia in adult-based research. These indices include mean platelet volume (MPV), platelet distribution width (PDW), and platelet-large cell ratio. The aim of the present study is to evaluate the variation and relationship of platelet indices in hypoproductive and hyperdestructive thrombocytopenia in children. MATERIALS AND METHODS: A prospective, observational study for a period of 1 year was done on children with thrombocytopenia. Platelet count (PLT), PDW, MPV, and platelet-large cell ratio (PLCR) along with relevant clinical details of the thrombocytopenic patients were collected and tested for the statistical significance by the unpaired t-test. RESULTS: This study included 80 patients of thrombocytopenia who were classified into hypoproductive (40 cases) and hyperdestructive (40 cases). The mean PLT in hypoproduction group is 49.3 ± 27.8 × 109/l and in hyperdestruction group is 45.7 ± 35.4 × 109/l with a P value of 0.548. The MPV in hypoproduction group is 9.3 ± 0.5 fl and in hyperdestruction group is 12.5 ± 1.7 fl, with a statistically significant P value of 0.002. The mean PDW in hypoproduction group is 16.3 ± 2.3 fl and in hyperdestruction group is 17.7 ± 2.8 fl with a P value of 0.055. The PLCR in hypoproduction group is 27.57% ±3.57% and in hyperdestruction group is 39.65% ±3.53% with a P value of 0.0003. CONCLUSION: Platelet indices may provide useful information in discriminating the hypoproductive and hyperdestructive thrombocytopenia in children too. Interpretation of platelet indices can help the thrombocytopenic children in the initial management and can avoid invasive investigations.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed146    
    Printed12    
    Emailed0    
    PDF Downloaded15    
    Comments [Add]    

Recommend this journal