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Cover page of the Journal of Health Sciences
MINI REVIEW ARTICLE
Year : 2021  |  Volume : 14  |  Issue : 1  |  Page : 22-30

Prostate-Specific antigen: An overview and its current status in the diagnosis of prostate cancer


Department of Urology, KLE Academy of Higher Education and Research (Deemed-to-be-University), Belagavi, Karnataka, India

Correspondence Address:
Dr. Siddalingeshwar Neeli
Department of Urology, KLE Academy of Higher Education and Research (Deemed-to-be-University), JNMC Campus, Belagavi - 590 010, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/kleuhsj.kleuhsj_97_19

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Prostate-Specific Antigen (PSA), which has high organ specificity and poor cancer specificity, has been widely utilized for the diagnosis and treatment of prostate cancer; though it is not an ideal tumor marker. Its extensive usage in screening programs has resulted in a large number of unwanted biopsies, over-diagnosis and over-treatment of indolent cancers as well. Hence, various PSA derivatives and PSA-based tests have evolved to improve the accuracy of prostate cancer diagnosis. This article provides an overview of PSA and PSA-based biomarkers and their current role in the screening and diagnosis of prostate cancer.


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