| MINI REVIEW ARTICLE |
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| Year : 2021 | Volume
: 14
| Issue : 1 | Page : 22-30 |
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Prostate-Specific antigen: An overview and its current status in the diagnosis of prostate cancer
Siddalingeshwar Neeli, Manas Sharma, Abhijit Musale
Department of Urology, KLE Academy of Higher Education and Research (Deemed-to-be-University), Belagavi, Karnataka, India
Correspondence Address:
Dr. Siddalingeshwar Neeli
Department of Urology, KLE Academy of Higher Education and Research (Deemed-to-be-University), JNMC Campus, Belagavi - 590 010, Karnataka
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/kleuhsj.kleuhsj_97_19
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Prostate-Specific Antigen (PSA), which has high organ specificity and poor cancer specificity, has been widely utilized for the diagnosis and treatment of prostate cancer; though it is not an ideal tumor marker. Its extensive usage in screening programs has resulted in a large number of unwanted biopsies, over-diagnosis and over-treatment of indolent cancers as well. Hence, various PSA derivatives and PSA-based tests have evolved to improve the accuracy of prostate cancer diagnosis. This article provides an overview of PSA and PSA-based biomarkers and their current role in the screening and diagnosis of prostate cancer.
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