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Cover page of the Journal of Health Sciences
Year : 2021  |  Volume : 14  |  Issue : 1  |  Page : 160-163

Histiocytic necrotizing lymphadenitis with systemic lupus erythematosus mimicking like lymphoma

1 Department of Laboratory Medicine, Yashoda Hospital, Hyderabad, Telangana, India
2 Department of Medicine, Yashoda Hospital, Hyderabad, Telangana, India
3 Department of Rheumatology, Yashoda Hospital, Hyderabad, Telangana, India
4 Department of Radiology, Yashoda Hospital, Hyderabad, Telangana, India

Correspondence Address:
Dr. Majed Abdul Basit Momin
Department of Laboratory Medicine, Yashoda Hospital, Malakpet, Nalgonda x-roads, Hyderabad - 500 036, Telangana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/kleuhsj.kleuhsj_258_20

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Histiocytic necrotizing lymphadenitis (HNL) is a rare idiopathic disorder. It is frequently underdiagnosed due to its nonspecific clinical features, mimicking like lymphomas, autoimmune diseases, and infectious reactive lymphadenopathy. Histological examination of the lymph node is the basis of diagnosis in HNL. We report a 40-year-old male patient who presented with fever for 4 weeks. After an extensive workup, laboratory investigations revealed progressive pancytopenia, gradual increase in serum lactate dehydrogenase, and ferritin with negative pyrexia profile. His radiological imaging including positron emission tomography/computed tomography showed multiple intra-abdominal, cervical, and axillary lymphadenopathies. Finally, the histological section from axillary lymph node core biopsy revealed a diagnosis of HNL. Subsequent autoimmune workup met diagnostic criteria for systemic lupus erythematosus. This case report alerts the clinicians regarding this rare disease and emphasizes the important role of morpho-histopathology in early recognition of this rare entity.

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