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Cover page of the Journal of Health Sciences
ORIGINAL ARTICLE
Year : 2020  |  Volume : 13  |  Issue : 3  |  Page : 230-234

Effect of tamoxifen-loaded transdermal patch on physical and biochemical parameters in DMBA-induced breast cancer


1 Department of Pharmaceutical Quality Assurance, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India
2 Department of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India

Correspondence Address:
Ms. Anjana Adhyapak
Department of Pharmaceutical Quality Assurance, KLE College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research, Belagavi - 590 010, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/kleuhsj.kleuhsj_38_20

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Background: The current study assessed the effect of tamoxifen-loaded transdermal patch in Dimethylbenz(a)anthracene (DMBA)-induced breast cancer. Materials and Methods: Different formulations composed of various concentrations of tamoxifen citrate, poly (SA: RA), glucose, mannitol were formulated and were evaluated in DMBAinduced breast cancer in female albino Wistar rats. Multiple parameters such as body weight, hemoglobin content, red blood cell, white blood cell, SGPT, and SGOT were evaluated. Results: Treatment with formulations showed a decrease in body weight contrast to disease. Equally, a considerable increase in hemoglobin was observed in the formulation treated group over disease grouping. Likewise, there decrease in SGPT and SGOT in formulation compared to disease. Conclusion: The present study revealed a transdermal patch loaded with tamoxifen showed promising antitumor activity.


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