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Cover page of the Journal of Health Sciences
ORIGINAL ARTICLE
Year : 2016  |  Volume : 9  |  Issue : 3  |  Page : 264-268

Formulation, characterization, and evaluation of orodispersible tablet of a model antidepressant drug


Department of Pharmaceutics, KLEU's College of Pharmacy, Hubballi, Karnataka, India

Correspondence Address:
Dr. V G Jamakandi
Department of Pharmaceutics, KLEU's College of Pharmacy, Vidyanagar, Hubballi, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2349-5006.196330

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Introduction: Paroxetine hydrochloride is used as the antidepressant drug of the selective serotonin reuptake inhibitor. It is used to treat depression resistant to other antidepressants, depression complicated by anxiety, panic disorder, obsessive-compulsive disorder (OCD). The objective of the present work is to formulate oral dispersible tablet dosage form using two different superdisintegrants. Materials and Methods: Eight formulations (F1-F8) were prepared using two superdisintegrants in varied concentrations. The optimized formulations (based on %CDR) were further formulated by sublimating agent using camphor as sublimating agent (S1, S2). Results and Discussion: All the formulated tablets were evaluated for physicochemical characteristics, drug content and in vitro drug release, dispersion time, and wetting time and the results were within the permissible limits. Conclusion: Orodispersible tablets of paroxetine HCl were successfully formulated by employing direct compression and sublimation methods. From this investigation, it can be concluded that stable orodispersible tablets gave maximum %CDR with 10% camphor as sublimating agent and 8% crospovidone as super disintegrant.


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