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Cover page of the Journal of Health Sciences
REVIEW ARTICLE
Year : 2018  |  Volume : 11  |  Issue : 1  |  Page : 3-11

Review of selected herbal phytoconstituents for potential melanoma treatment


1 Dr. Prabhakar Kore Basic Science Research Center, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India
2 Dr. Prabhakar Kore Basic Science Research Center, KLE Academy of Higher Education and Research; Department of Pharmacognosy and Phytochemistry, KLE University's College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India

Correspondence Address:
Sunil Satyappa Jalalpure
KLE University's College of Pharmacy, KLE Academy of Higher Education and Research, Nehru Nagar, Belagavi - 590 010, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/kleuhsj.kleuhsj_319_17

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Malignant melanoma is the most aggressive form of skin cancer, with a high mortality rate. The current chemotherapies have a relatively low success rate due to the development of multidrug resistance and side effects. Hence, there is need of discovering new compounds that are safe and more effective against melanoma to improve the efficiency and to lower the treatment cost for cancer care. Melanoma chemoprevention with natural herbal phytoconstituents is an emerging strategy to prevent, cure, or treat melanoma. This review summarizes the latest research in melanoma chemoprevention and treatment using the herbal phytoconstituents. Relevant mechanisms involved in the pharmacological effects of these phytochemical are discussed. Phytoconstituents that are discussed in this review are carotenoids, flavonoids, some polyphenols, piperine alkaloid, and sulforaphane having high anticancer potential mostly to be used for the treatment of melanoma.


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